Vincent J. O’Neill M.D.
Executive Vice President, Chief of Product Development and Medical Officer
Dr. Vince O’Neill has significant expertise in therapeutic and diagnostic product development. He joined BioXcel Therapeutics in 2017 as Vice President and Chief Medical Officer, later Senior Vice President and Chief Medical Officer, and played an instrumental role in the Company’s SERENITY I and II trials of BXCL501, which contributed to the FDA approval of IGALMI™ (dexmedetomidine) sublingual film for the acute treatment of agitation associated with schizophrenia and bipolar I or II disorder in adults. He also led the Company’s immuno-oncology program and the successful human proof of concept trials for BXCL701, an investigational, orally administered systemic innate immune activator for the treatment of refractory forms of prostate cancer. In 2022, he became Senior Vice President and Chief Research & Development Officer of the Company’s wholly owned OnkosXcel Therapeutics subsidiary.
Prior to joining BioXcel Therapeutics, Dr. O’Neill held senior leadership roles at several leading global pharmaceutical companies, including Sanofi, Genentech, and GlaxoSmithKline. Most recently, he served as Chief Medical Officer at Mirna Therapeutics and Exosome Diagnostics. He was instrumental in the expanded approvals of Genentech’s oncology therapeutics, Avastin® and Tarceva®. At GSK, he oversaw the signal transduction discovery unit and led the first IND application and clinical trial of the MEK inhibitor, MEKINIST®. Dr. O’Neill has authored several peer-reviewed publications and conference presentations. He received his M.D. and B.Sc. in Molecular Pathology from the University of Glasgow, Scotland, and is a member of the Royal College of Physicians.
Prior to joining BioXcel Therapeutics, Dr. O’Neill held senior leadership roles at several leading global pharmaceutical companies, including Sanofi, Genentech, and GlaxoSmithKline. Most recently, he served as Chief Medical Officer at Mirna Therapeutics and Exosome Diagnostics. He was instrumental in the expanded approvals of Genentech’s oncology therapeutics, Avastin® and Tarceva®. At GSK, he oversaw the signal transduction discovery unit and led the first IND application and clinical trial of the MEK inhibitor, MEKINIST®. Dr. O’Neill has authored several peer-reviewed publications and conference presentations. He received his M.D. and B.Sc. in Molecular Pathology from the University of Glasgow, Scotland, and is a member of the Royal College of Physicians.